Increased density of dopamine D2 receptors in the putamen, but not in the caudate nucleus in early Parkinson's disease: a PET study with [11C]raclopride
Identifieur interne : 002247 ( Main/Exploration ); précédent : 002246; suivant : 002248Increased density of dopamine D2 receptors in the putamen, but not in the caudate nucleus in early Parkinson's disease: a PET study with [11C]raclopride
Auteurs : Juha O. Rinne [Finlande] ; Arto Laihinen [Finlande] ; Hanna Ruottinen [Finlande] ; Ulla Ruotsalainen [Finlande] ; Kjell N Gren [Finlande] ; Pertti Lehikoinen [Finlande] ; Vesa Oikonen [Finlande] ; U. K. Rinne [Finlande]Source :
- Journal of the Neurological Sciences [ 0022-510X ] ; 1995.
Abstract
Striatal dopamine D2 receptors were studied, using positron emission tomography (PET), in 10 patients with early Parkinson's disease without any antiparkinsonian medication and in 14 healthy controls. [11C]Raclopride was used as ligand and an equilibrium method was applied. The maximum count of receptors (Bmax) and their dissociation constant (Kd) were calculated according to the Scatchard principle. In parkinsonian patients, the Bmax of D2 receptors was increased in the putamen contralateral to the predominant symptoms, as compared to the opposite putamen, by 33% (p = 0.0008). In the caudate nucleus no significant side to side differences was noted. On comparison with age-matched healthy controls, Bmax values in the putamen (p = 0.0012) but not in the caudate nucleus contralateral to the side of predominant clinical symptoms were increased in PD patients. The Kd values were unchanged. The difference in putaminal Bmax values between the opposite hemispheres correlated with the difference in the severity of parkinsonian motor symptoms between the two body sides (r = 0.69, p = 0.03). The present results show that there is both a relative and absolute increase in the number of dopamine D2 receptors in the putamen, but not in the caudate nucleus in early Parkinson's disease.
Url:
DOI: 10.1016/0022-510X(95)00137-Q
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Increased density of dopamine D2 receptors in the putamen, but not in the caudate nucleus in early Parkinson's disease: a PET study with [11C]raclopride</title><author><name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O." last="Rinne">Juha O. Rinne</name></author><author><name sortKey="Laihinen, Arto" sort="Laihinen, Arto" uniqKey="Laihinen A" first="Arto" last="Laihinen">Arto Laihinen</name></author><author><name sortKey="Ruottinen, Hanna" sort="Ruottinen, Hanna" uniqKey="Ruottinen H" first="Hanna" last="Ruottinen">Hanna Ruottinen</name></author><author><name sortKey="Ruotsalainen, Ulla" sort="Ruotsalainen, Ulla" uniqKey="Ruotsalainen U" first="Ulla" last="Ruotsalainen">Ulla Ruotsalainen</name></author><author><name sortKey="N Gren, Kjell" sort="N Gren, Kjell" uniqKey="N Gren K" first="Kjell" last="N Gren">Kjell N Gren</name></author><author><name sortKey="Lehikoinen, Pertti" sort="Lehikoinen, Pertti" uniqKey="Lehikoinen P" first="Pertti" last="Lehikoinen">Pertti Lehikoinen</name></author><author><name sortKey="Oikonen, Vesa" sort="Oikonen, Vesa" uniqKey="Oikonen V" first="Vesa" last="Oikonen">Vesa Oikonen</name></author><author><name sortKey="Rinne, U K" sort="Rinne, U K" uniqKey="Rinne U" first="U. K." last="Rinne">U. K. Rinne</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:809F6EC7C0EA6A5FF989A13C81E2B878D81F912B</idno><date when="1995" year="1995">1995</date><idno type="doi">10.1016/0022-510X(95)00137-Q</idno><idno type="url">https://api.istex.fr/document/809F6EC7C0EA6A5FF989A13C81E2B878D81F912B/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002279</idno><idno type="wicri:Area/Main/Curation">001F64</idno><idno type="wicri:Area/Main/Exploration">002247</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Increased density of dopamine D2 receptors in the putamen, but not in the caudate nucleus in early Parkinson's disease: a PET study with [11C]raclopride</title><author><name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O." last="Rinne">Juha O. Rinne</name><affiliation wicri:level="4"><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Neurology, University of Turku, SF-20520 Turku</wicri:regionArea><orgName type="university">Université de Turku</orgName><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author><author><name sortKey="Laihinen, Arto" sort="Laihinen, Arto" uniqKey="Laihinen A" first="Arto" last="Laihinen">Arto Laihinen</name><affiliation wicri:level="4"><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Neurology, University of Turku, SF-20520 Turku</wicri:regionArea><orgName type="university">Université de Turku</orgName><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author><author><name sortKey="Ruottinen, Hanna" sort="Ruottinen, Hanna" uniqKey="Ruottinen H" first="Hanna" last="Ruottinen">Hanna Ruottinen</name><affiliation wicri:level="4"><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Neurology, University of Turku, SF-20520 Turku</wicri:regionArea><orgName type="university">Université de Turku</orgName><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author><author><name sortKey="Ruotsalainen, Ulla" sort="Ruotsalainen, Ulla" uniqKey="Ruotsalainen U" first="Ulla" last="Ruotsalainen">Ulla Ruotsalainen</name><affiliation wicri:level="3"><country xml:lang="fr">Finlande</country><wicri:regionArea>Turku University Cyclotron-PET Center, PET Unit, Turku</wicri:regionArea><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author><author><name sortKey="N Gren, Kjell" sort="N Gren, Kjell" uniqKey="N Gren K" first="Kjell" last="N Gren">Kjell N Gren</name><affiliation wicri:level="3"><country xml:lang="fr">Finlande</country><wicri:regionArea>Turku University Cyclotron-PET Center, Radiopharmaceutical Chemistry Laboratory, University of Turku, Turku</wicri:regionArea><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author><author><name sortKey="Lehikoinen, Pertti" sort="Lehikoinen, Pertti" uniqKey="Lehikoinen P" first="Pertti" last="Lehikoinen">Pertti Lehikoinen</name><affiliation wicri:level="3"><country xml:lang="fr">Finlande</country><wicri:regionArea>Turku University Cyclotron-PET Center, Radiopharmaceutical Chemistry Laboratory, University of Turku, Turku</wicri:regionArea><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author><author><name sortKey="Oikonen, Vesa" sort="Oikonen, Vesa" uniqKey="Oikonen V" first="Vesa" last="Oikonen">Vesa Oikonen</name><affiliation wicri:level="4"><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Neurology, University of Turku, SF-20520 Turku</wicri:regionArea><orgName type="university">Université de Turku</orgName><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author><author><name sortKey="Rinne, U K" sort="Rinne, U K" uniqKey="Rinne U" first="U. K." last="Rinne">U. K. Rinne</name><affiliation wicri:level="4"><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Neurology, University of Turku, SF-20520 Turku</wicri:regionArea><orgName type="university">Université de Turku</orgName><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of the Neurological Sciences</title><title level="j" type="abbrev">JNS</title><idno type="ISSN">0022-510X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1995">1995</date><biblScope unit="volume">132</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="156">156</biblScope><biblScope unit="page" to="161">161</biblScope></imprint><idno type="ISSN">0022-510X</idno></series><idno type="istex">809F6EC7C0EA6A5FF989A13C81E2B878D81F912B</idno><idno type="DOI">10.1016/0022-510X(95)00137-Q</idno><idno type="PII">0022-510X(95)00137-Q</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-510X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Striatal dopamine D2 receptors were studied, using positron emission tomography (PET), in 10 patients with early Parkinson's disease without any antiparkinsonian medication and in 14 healthy controls. [11C]Raclopride was used as ligand and an equilibrium method was applied. The maximum count of receptors (Bmax) and their dissociation constant (Kd) were calculated according to the Scatchard principle. In parkinsonian patients, the Bmax of D2 receptors was increased in the putamen contralateral to the predominant symptoms, as compared to the opposite putamen, by 33% (p = 0.0008). In the caudate nucleus no significant side to side differences was noted. On comparison with age-matched healthy controls, Bmax values in the putamen (p = 0.0012) but not in the caudate nucleus contralateral to the side of predominant clinical symptoms were increased in PD patients. The Kd values were unchanged. The difference in putaminal Bmax values between the opposite hemispheres correlated with the difference in the severity of parkinsonian motor symptoms between the two body sides (r = 0.69, p = 0.03). The present results show that there is both a relative and absolute increase in the number of dopamine D2 receptors in the putamen, but not in the caudate nucleus in early Parkinson's disease.</div></front></TEI><affiliations><list><country><li>Finlande</li></country><region><li>Finlande occidentale</li></region><settlement><li>Turku</li></settlement><orgName><li>Université de Turku</li></orgName></list><tree><country name="Finlande"><region name="Finlande occidentale"><name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O." last="Rinne">Juha O. Rinne</name></region><name sortKey="Laihinen, Arto" sort="Laihinen, Arto" uniqKey="Laihinen A" first="Arto" last="Laihinen">Arto Laihinen</name><name sortKey="Lehikoinen, Pertti" sort="Lehikoinen, Pertti" uniqKey="Lehikoinen P" first="Pertti" last="Lehikoinen">Pertti Lehikoinen</name><name sortKey="N Gren, Kjell" sort="N Gren, Kjell" uniqKey="N Gren K" first="Kjell" last="N Gren">Kjell N Gren</name><name sortKey="Oikonen, Vesa" sort="Oikonen, Vesa" uniqKey="Oikonen V" first="Vesa" last="Oikonen">Vesa Oikonen</name><name sortKey="Rinne, U K" sort="Rinne, U K" uniqKey="Rinne U" first="U. K." last="Rinne">U. K. Rinne</name><name sortKey="Ruotsalainen, Ulla" sort="Ruotsalainen, Ulla" uniqKey="Ruotsalainen U" first="Ulla" last="Ruotsalainen">Ulla Ruotsalainen</name><name sortKey="Ruottinen, Hanna" sort="Ruottinen, Hanna" uniqKey="Ruottinen H" first="Hanna" last="Ruottinen">Hanna Ruottinen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002247 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002247 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:809F6EC7C0EA6A5FF989A13C81E2B878D81F912B
|texte= Increased density of dopamine D2 receptors in the putamen, but not in the caudate nucleus in early Parkinson's disease: a PET study with [11C]raclopride
}}
| This area was generated with Dilib version V0.6.23. |  |